| 韦玉连,唐耀平.“消脂化斑方”联合西药治疗痰浊血瘀型颈动脉粥样硬化斑块64例临床研究[J].江苏中医药,0,():. |
| “消脂化斑方”联合西药治疗痰浊血瘀型颈动脉粥样硬化斑块64例临床研究 |
| Clinical study on 64 patients of carotid atherosclerotic plaque of phlegm turbid blood stasis type treated by "Xiaozhihuaban Recipe" combined with atorvastatin calcium tablets |
| 投稿时间：2023-12-05 修订日期：2024-03-03 |
| DOI： |
| 中文关键词: 颈动脉粥样硬化斑块 痰浊血瘀证 因虚致邪 微观辨证，消脂化斑方 |
| 英文关键词: Carotid atherosclerotic plaque phlegm turbid blood stasis type evil due to deficiency microscopic syndrome differentiation Xiaozhihuaban Recipe |
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| 中文摘要: |
| 目的：观察自拟消脂化斑方联合阿托伐他汀钙片治疗痰浊血瘀型颈动脉粥样硬化斑块患者的临床疗效；基于“因虚致邪”理论，为治疗颈动脉粥样硬化斑块提供一种组方策略，为中医辨证进一步拓展深度。方法：64例痰浊血瘀型颈动脉粥样硬化斑块患者被随机分为对照组和观察组，每组32例。对照组给予阿托伐他汀钙片，观察组在对照组基础上加用消脂化斑方治疗，两组疗程均为12周，观察并比较两组患者治疗前后的各项指标，包括中医证候积分、TC、TG、LDL-C、HDL-C、斑块Crouse积分、IMT及安全性指标等变化，并评估临床疗效及安全性。结果：两组患者治疗后中医症候积分、TC、TG、LDL-C、HDL-C、斑块Crouse积分、IMT较治疗前均有改善（P＜0.05），且观察组中医症候积分、TC、LDL-C、HDL-C、斑块Crouse积分、IMT改善较对照组明显（P＜0.05），观察组TG指标与对照组比较，P＞0.05；两组不良反应均较少，P＞0.05。结论：在常规西药治疗的基础上联合消脂化斑方能有效改善痰浊血瘀型颈动脉粥样硬化斑块患者的临床症状，调节血脂指标，降低斑块Crouse积分及IMT，提高临床疗效，具有良好的安全性。 |
| 英文摘要: |
| Objective: To observe the clinical efficacy of self-made Xiaozhihuaban Recipe combined with atorvastatin calcium tablets in the treatment of carotid atherosclerotic plaque of phlegm and blood stasis type; Based on the theory of "pathogenic due to deficiency", it provides a prescription strategy for the treatment of carotid atherosclerotic plaque, and further expands the depth of of Traditional Chinese Medicine (TCM)syndrome differentiation.Methods:64 patients with carotid atherosclerotic plaque of phlegm turbid blood stasis type were randomly divided into control group and observation group, with 32 cases in each group. The control group was given atorvastatin calcium tablets, while the observation group was treated with Xiaozhihuaban Recipe on the basis of the control group. Both groups had a treatment period of 12 weeks. The various indicators of the two groups of patients before and after treatment were observed and compared, including changes in traditional Chinese medicine syndrome score, TC, TG, LDL-C, HDL-C, plaque Crouse score, IMT, and safety indicators. Clinical efficacy and safety were also evaluated.Result:After treatment, the TCM syndrome score, TC, TG, LDL-C, HDL-C, plaque Crouse score, and IMT of both groups of patients improved compared to before treatment (P<0.05), and the observation group showed significant improvement in TCM syndrome score, TC, LDL-C, HDL-C, plaque Crouse score, and IMT compared to the control group (P<0.05). The TG index of the observation group was compared to the control group, P>0.05; Both groups had fewer adverse reactions, P>0.05.Conclusion:On the basis of conventional western medicine treatment, the combination of Xiaozhihuaban Recipe can effectively improve the clinical symptoms of carotid atherosclerotic plaque patients with phlegm and blood stasis, regulate blood lipid indicators, reduce plaque Crouse score and IMT, improve clinical efficacy, and have good safety. |
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